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KMID : 0353320020260010161
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Oral Biology Research
2002 Volume.26 No. 1 p.161 ~ p.171
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Tow-dimensional electrophoretic analysis in osteoclast differentiation
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Abstract
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Osteoclasts, cells primarily involved in osteoporosis, are originated from the hematopoietic precursor cells of the monocyte/macrophage lineage. Proteins involved in osteoclast differentiation could be targets for drug development of osteoporosis therapy. To characterize protein expression pattern during osteoclastogenesis, we have carried out two-dimensional electrophoreses using cellular extracts from RAW 264.7 cells and mouse bone-marrow cells before and after differentiation into osteoclast-like cells. Several protein spots were found changed during differentiation. These data can serve protein expression maps for osteoclastogenesis and provide information for further analyses with MALDI-TOF for identification of the regulated proteins.
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